Amsterdam UMC-Location Academic Medical Center, Amsterdam, the Netherlands. Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA. Electronic address: renato.lopes@dm.duke.edu. Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA. Canadian VIGOUR Center, University of Alberta, Edmonton, Alberta, Canada; St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada. Bristol Myers Squibb, Lawrenceville, New Jersey, USA. Bern University Hospital, Inselspital, Bern, Switzerland. The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, and Cardiovascular Research Foundation, New York, New York, USA.